{"id":2332,"date":"2010-05-28T17:21:04","date_gmt":"2010-05-28T15:21:04","guid":{"rendered":"http:\/\/localhost\/azgad\/wordpress\/?p=2332"},"modified":"2010-05-29T15:37:26","modified_gmt":"2010-05-29T13:37:26","slug":"proper-maturation-of-the-visual-cortex-in-mice-and-possibly-humans-depends-on-a-maternal-gene","status":"publish","type":"post","link":"https:\/\/azgad.com\/?p=2332","title":{"rendered":"Proper maturation of the visual cortex in mice, and possibly humans, depends on a maternal gene"},"content":{"rendered":"

.
\n \u05d4\u05d7\u05dc\u05e7 \u05d4\u05d9\u05d5\u05ea\u05e8 \u05d2\u05d3\u05d5\u05dc \u05e9\u05dc \u05de\u05d5\u05d7\u05e0\u05d5, \u05de\u05d5\u05e7\u05d3\u05e9 \u05dc\u05e2\u05d9\u05d1\u05d5\u05d3 \u05e9\u05dc \u05d0\u05d5\u05ea\u05d5\u05ea \u05d4\u05e8\u05d0\u05d9\u05d9\u05d4.
\n \u05e2\u05db\u05e9\u05d9\u05d5 \u05de\u05ea\u05d1\u05e8\u05e8 \u05e9\u05d2\u05df \u05de\u05e1\u05d5\u05d9\u05dd, \u05e9\u05d0\u05d5\u05ea\u05d5 \u05d0\u05e0\u05d5 \u05d9\u05d5\u05e8\u05e9\u05d9\u05dd \u05de\u05d0\u05d9\u05de\u05d5\u05ea\u05d9\u05e0\u05d5 \u05d1\u05dc\u05d1\u05d3,
\n\u05d4\u05d5\u05d0 \u05d4\u05d0\u05d7\u05e8\u05d0\u05d9 \u05dc\u05d4\u05ea\u05e4\u05ea\u05d7\u05d5\u05ea \u05d4\u05ea\u05e7\u05d9\u05e0\u05d4 \u05e9\u05dc \u05d4\u05d0\u05d9\u05d6\u05d5\u05e8 \u05d4\u05d6\u05d4 \u05d1\u05de\u05d5\u05d7.
\n\u05d0\u05de\u05d0 \u05d9\u05e9 \u05e8\u05e7 \u05d0\u05d7\u05ea, \u05d5\u05d4\u05d9\u05d0 \u05e7\u05d5\u05d1\u05e2\u05ea \u05d0\u05ea \u05d4\u05d3\u05e8\u05da \u05e9\u05d1\u05d4 \u05d0\u05e0\u05d5 \u05e8\u05d5\u05d0\u05d9\u05dd \u05d0\u05ea
\n\u05d4\u05e2\u05d5\u05dc\u05dd.<\/strong>.<\/p>\n

The copy of the gene Ube3a inherited from the mother\u2014not the father\u2014is
\n crucial to proper wiring of the visual cortex in mice after birth, a RIKEN
\nresearcher and his American co-worker have found In human babies,
\n a defective maternal Ube3a gene causes a developmental condition
\n known as Angelman syndrome that leads to mental retardation, speech
\n impairment and brain seizures, and affects behavior. The researchers therefore
\n suggest that stimulating the silenced paternal gene at the right time of
\n development might be worth exploring as therapy for this syndrome.
\n.
\nNerve cell wiring of the visual cortex of the brain occurs after birth, and is
\n then refined by experience. Typically, images are constructed
\nusing signals from nerve cells that receive more input from one eye than
\nthe other, an occurrence known as ocular dominance (OD). The balance
\n of OD displays plasticity; it can be altered, for instance, by temporarily blinding
\none eye during the critical period of development when the interconnections
\n of nerve cells in the brain are susceptible to experience.
\n.
\nMasaaki Sato from the RIKEN Brain Science Institute, Wako, and Michael Stryker from
\nthe University of California, San Francisco, confirmed in mice that by about four weeks
\n of age\u2014their critical period of development\u2014the presence of the Ube3a protein is mainly
\nrestricted to the nucleus of nerve cells in the visual cortex of the brain; and it is dependent
\n on the maternal gene.
\n.
\nThe researchers then investigated how the interconnections of the nerve cells could be
\n changed before, during and after the critical period. They tested these changes using
\noptical imaging, a technique that can provide information on activity in the brain. They
\nfound that both maternal and paternal copies of the gene contributed to normal development
\n until the critical period. From this stage on, however, the maternal copy alone was active
\n and required for maturation of the cortical circuits. Without the maternal gene the visual
\n system did not rapidly adjust OD to the experience of having one eye briefly blinded during
\nthe critical period. And afterwards, there was impairment of the ability to make the minor
\n wiring adjustments as the system matured.
\n.
\n\u201cWe now want to investigate how Ube3a participates in the maturation process of cortical
\nneuronal circuits,\u201d Sato says. \u201cThe other direction [of our work] will be to screen genes or
\n compounds which have potential to restore the impaired plasticity of
\nUbe3a maternal-deficient mice.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

. \u05d4\u05d7\u05dc\u05e7 \u05d4\u05d9\u05d5\u05ea\u05e8 \u05d2\u05d3\u05d5\u05dc \u05e9\u05dc \u05de\u05d5\u05d7\u05e0\u05d5, \u05de\u05d5\u05e7\u05d3\u05e9 \u05dc\u05e2\u05d9\u05d1\u05d5\u05d3 \u05e9\u05dc \u05d0\u05d5\u05ea\u05d5\u05ea \u05d4\u05e8\u05d0\u05d9\u05d9\u05d4. \u05e2\u05db\u05e9\u05d9\u05d5 \u05de\u05ea\u05d1\u05e8\u05e8 \u05e9\u05d2\u05df \u05de\u05e1\u05d5\u05d9\u05dd, \u05e9\u05d0\u05d5\u05ea\u05d5 \u05d0\u05e0\u05d5 \u05d9\u05d5\u05e8\u05e9\u05d9\u05dd \u05de\u05d0\u05d9\u05de\u05d5\u05ea\u05d9\u05e0\u05d5 \u05d1\u05dc\u05d1\u05d3, \u05d4\u05d5\u05d0 \u05d4\u05d0\u05d7\u05e8\u05d0\u05d9 \u05dc\u05d4\u05ea\u05e4\u05ea\u05d7\u05d5\u05ea \u05d4\u05ea\u05e7\u05d9\u05e0\u05d4 \u05e9\u05dc \u05d4\u05d0\u05d9\u05d6\u05d5\u05e8 \u05d4\u05d6\u05d4 \u05d1\u05de\u05d5\u05d7. \u05d0\u05de\u05d0 \u05d9\u05e9 \u05e8\u05e7 \u05d0\u05d7\u05ea, \u05d5\u05d4\u05d9\u05d0 \u05e7\u05d5\u05d1\u05e2\u05ea \u05d0\u05ea \u05d4\u05d3\u05e8\u05da \u05e9\u05d1\u05d4 \u05d0\u05e0\u05d5 \u05e8\u05d5\u05d0\u05d9\u05dd \u05d0\u05ea \u05d4\u05e2\u05d5\u05dc\u05dd.. The copy of the gene Ube3a inherited from the mother\u2014not the father\u2014is crucial to … <\/p>\n

\u05d4\u05de\u05e9\u05d9\u05db\u05d5 \u05d1\u05e7\u05e8\u05d9\u05d0\u05d4<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[10],"tags":[136,273,513,186],"class_list":["post-2332","post","type-post","status-publish","format-standard","hentry","category-10","tag-136","tag-273","tag-513","tag-186","nodate","item-wrap"],"_links":{"self":[{"href":"https:\/\/azgad.com\/index.php?rest_route=\/wp\/v2\/posts\/2332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/azgad.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/azgad.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/azgad.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/azgad.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2332"}],"version-history":[{"count":5,"href":"https:\/\/azgad.com\/index.php?rest_route=\/wp\/v2\/posts\/2332\/revisions"}],"predecessor-version":[{"id":2342,"href":"https:\/\/azgad.com\/index.php?rest_route=\/wp\/v2\/posts\/2332\/revisions\/2342"}],"wp:attachment":[{"href":"https:\/\/azgad.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/azgad.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/azgad.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}