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Researchers from the Charit\u00e9 University Medical School, the Max Delbr\u00fcck Center for Molecular Medicine (MDC) in Berlin, Germany and the University of Leeds, UK, have discovered a new driving force behind cancer growth. Their studies have identified how \u2018junk\u2019 DNA promotes the growth of cancer cells in patients with Hodgkin\u2019s lymphoma. Dr Stephan Mathas (Charit\u00e9, MDC) and Professor Constanze Bonifer (University of Leeds) suspect that these pieces of \u2018junk\u2019 DNA, called \u2018long terminal repeats\u2019, can play a role in other forms of cancer as well. The researchers uncovered the process by which this \u2018junk DNA\u2019 is made active, promoting cancer growth (Nature Medicine, doi 10.1038\/nm.2129)*.<\/p>\n
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\u201cWe have shown this is the case in Hodgkin\u2019s lymphoma, but the exact same mechanism could be involved in the development of other forms of blood cancer,\u201d said Prof. Bonifer. \u201cThis would have implications for diagnosis, prognosis, and therapy of these diseases.\u201d<\/p>\n
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\u2018Long terminal repeats\u2019 (LTRs) are a form of \u2018junk DNA\u2019 – genetic material that has accumulated in the human genome over millions of years. Although LTRs originate from viruses and are potentially harmful, they are usually made inactive when embryos are developing in the womb.<\/p>\n
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If this process of inactivation doesn\u2019t work, then the LTRs could activate cancer genes, a possibility that was suggested in previous animal studies. This latest research has now demonstrated for the first time that these \u2018rogue\u2019 active LTRs can drive the growth of cancer in humans.<\/p>\n
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The work focused on cancerous cells of Hodgkin\u2019s lymphoma (the Hodgkin-\/Reed Sternberg cells) that originate from white blood cells (antibody-producing B cells). Unusually, this type of lymphoma cell does not contain a so-called \u2018growth factor receptor\u2019 that normally controls the growth of other B-cells. <\/p>\n
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They found that the lymphoma cells\u2019 growth was dependent on a receptor that normally regulates the growth of other immune cells, but it is not usually found in B-cells. However in this case, the Hodgkin-\/Reed Sternberg cells \u2018hijacked\u2019 this receptor (CSF1R, the colony stimulating factor 1 receptor) for their own purposes by activating some of the \u2018junk DNA\u2019. In fact the lymphoma cells activated hundreds, if not thousands, of LTRs all over the genome, not just one. <\/p>\n
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Hodgkin-\/Reed Sternberg cells may not be the only cells that use this method to subvert normal controls of cell growth. The researchers found evidence of the same LTRs activating the same growth receptor in anaplastic large cell lymphoma, another blood cancer. <\/p>\n
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The consequences of such widespread LTR activation are currently still unclear, according to the study\u2019s authors. Such processes could potentially activate other genes involved in tumour development. It could also affect the stability of chromosomes of lymphoma cells, a factor that may explain why Hodgkin-\/Reed Sternberg cells gain many chromosomal abnormalities over time and become more and more malignant.
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. Researchers from the Charit\u00e9 University Medical School, the Max Delbr\u00fcck Center for Molecular Medicine (MDC) in Berlin, Germany and the University of Leeds, UK, have discovered a new driving force behind cancer growth. Their studies have identified how \u2018junk\u2019 DNA promotes the growth of cancer cells in patients with Hodgkin\u2019s lymphoma. Dr Stephan Mathas … <\/p>\n